Cryoglobulinemia
[printfriendly] Cryoglobulinemia (which literally means “cold antibody in the blood”) refers to chemical properties of the antibodies that cause this disease. Cryoglobulins are antibodies that precipitate, or clump together, under cold conditions. People with cryoglobulinemia experience the characteristic symptoms – paleness, numbness, and pain in extremities, bleeding under the skin, and joint pain — when …