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Subject: Drug Combination Improves Survival in Pancreatic Cancer
Date: Fri, 6 Aug 2010 09:14:23 -0500
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                <TD><FONT style=3D"FONT-SIZE: 9px"=20
                  face=3D"Verdana, Arial, Helvetica, sans-serif"=20
                  color=3D#666666>ISSUE: AUGUST,=20
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</TD></TR></TBODY></TABLE><BR><STRONG><FONT=20
            face=3D"Verdana, Arial, Helvetica, sans-serif" size=3D4>Drug =
Combination=20
            Improves Survival in Pancreatic Cancer </FONT></STRONG>
            <P><FONT face=3D"Verdana, Arial, Helvetica, sans-serif" =
size=3D1>Kate=20
            O=92Rourke<BR></FONT></P>
        <TR>
          <TD class=3Dbody>
            <H2><SPAN class=3DApple-style-span=20
            style=3D"FONT-WEIGHT: normal; FONT-SIZE: =
13px">Chicago=97Clinicians have=20
            a new regimen to consider for the first-line treatment of =
certain=20
            patients with metastatic pancreatic cancer. First-line =
therapy with=20
            FOLFIRINOX, a combination of older chemotherapeutic drugs, =
improved=20
            median overall survival (OS) of certain patients with =
pancreatic=20
            cancer by four months (11.1 vs. 6.8 months) compared with=20
            gemcitabine (Gemzar, Eli Lilly). The dramatic news comes =
from a=20
            study by French researchers presented at the annual meeting =
of the=20
            American Society of Clinical Oncology (abstract =
4010).</SPAN></H2>
            <P><IMG alt=3D"" hspace=3D7=20
            =
src=3D"http://www.clinicaloncology.com/aimages/2010/con0810_018_graphic_d=
300.jpg"=20
            align=3Dright vspace=3D7 border=3D0>=93It has been =
vanishingly rare for an=20
            abstract in pancreas cancer to be practice-changing. This =
one=20
            probably is,=94 commented Leonard Saltz, MD, professor of =
medicine at=20
            Memorial Sloan-Kettering Cancer Center, in New York City. =
=93The=20
            outcome in the experimental arm was superior compared to the =

            gemcitabine control arm; however, it was at a considerable =
price in=20
            terms of toxicity. This is not a new standard of care=97it =
is a new=20
            standard option. It is a reasonable consideration =
<I>only</I> in=20
            patients with excellent performance status [PS)]=97Eastern =
Cooperative=20
            Oncology Group status 0 or 1=97and within that population, =
the=20
            benefits versus toxicities need to be carefully discussed =
with each=20
            individual patient. It will be right for some, and not for=20
            others.=94</P>
            <P>The study=92s lead researcher agreed that the regimen was =
only for=20
            certain patients. =93This is the first time in a randomized =
Phase III=20
            study that we have achieved an 11-month median overall =
survival [OS]=20
            in pancreatic cancer,=94 said Thierry Conroy, MD, the Centre =
Alexis=20
            Vautrin and Nancy University, in Vandoeuvre-l=E8s-Nancy, =
France. =93We=20
            recommend FOLFIRINOX as the new international standard of =
care for=20
            patients with metastatic pancreatic cancer, but only in =
patients=20
            with normal or [near] normal level of bilirubin and =
performance=20
            status 0 or 1.=94 He said that the regimen delayed =
deterioration of=20
            quality of life. =93FOLFIRINOX is more toxic, but overall =
has very=20
            manageable toxicities,=94 Dr. Conroy said.</P>
            <P>Ed Chu, chief of the Section of Medical Oncology and =
deputy=20
            director of clinical research at Yale Cancer Center, Yale=20
            University, in New Haven, Conn, speculated whether the =
regimen could=20
            be used in another setting. =93Perhaps another setting to =
use this=20
            regimen would be locally advanced pancreatic cancer, where =
tumor=20
            reduction could lead to better surgical outcomes,=94 Dr. Chu =
said. =93It=20
            is probably similar in concept to using FOLFOXIRI in the =
treatment=20
            of [metastatic colorectal cancer].=94</P>
            <P>In the French trial, 342 patients with metastatic =
pancreatic=20
            adenocarcinoma were randomized to standard treatment with=20
            gemcitabine or FOLFIRINOX (F), which is a combination of=20
            5-fluorouracil (5-FU), leucovorin, irinotecan and =
oxaliplatin.=20
            Patients were required to have adequate organ function, a PS =
of 0 or=20
            1, bilirubin less than 1.5 upper limit of normal and no =
prior=20
            chemotherapy or radiotherapy. Patients were not included if =
they had=20
            non-ductal pancreatic cancer; adenocarcinoma of the ampulla =
of=20
            Vater; unresectable, locally advanced pancreatic cancer =
without=20
            distant metastases; central nervous system metastases; =
chronic=20
            diarrhea; or other previous or concomitant malignant =
disease.</P>
            <P>Patients aged 18 to 75 years (median, 60 years) were =
stratified=20
            by center, PS and primary tumor location. Specifically, =
patients in=20
            the FOLFIRINOX arm received oxaliplatin (85 mg/m<SUP=20
            style=3D"LINE-HEIGHT: 0px">2</SUP> over two hours), =
leucovorin (400=20
            mg/m<SUP style=3D"LINE-HEIGHT: 0px">2</SUP> over two hours), =

            irinotecan (180 mg/m<SUP style=3D"LINE-HEIGHT: 0px">2</SUP> =
over 90=20
            minutes), and 5-FU (400 mg/m<SUP style=3D"LINE-HEIGHT: =
0px">2</SUP>=20
            bolus then 2,400 mg/m<SUP style=3D"LINE-HEIGHT: 0px">2</SUP> =
over 46=20
            hours), all on day 1, and then repeated every two weeks. =
Patients in=20
            the control arm received gemcitabine (1,000 mg/m<SUP=20
            style=3D"LINE-HEIGHT: 0px">2</SUP> IV over 30 minutes weekly =
for seven=20
            of eight weeks, one week rest, and then weekly for three of =
four=20
            weeks). The two study arms were well balanced for baseline=20
            characteristics.</P>
            <P>At the planned interim analysis, the Independent Data =
Monitoring=20
            Committee recommended that the study be halted when it was=20
            determined that the median OS was significantly increased=20
            (<I>P</I>&lt;0.0001) and that the findings were unlikely to =
change=20
            with additional patients. At the final analysis, the median =
OS was=20
            6.8 months for gemcitabine compared with 11.1 months in the=20
            FOLFIRINOX arm (hazard ratio [HR], 0.57; <I>P</I>&lt;0.0001) =
(Figure=20
            1). Median progression-free survival was 6.4 months in the=20
            FOLFIRINOX arm and 3.3 months in patients receiving =
gemcitabine (HR,=20
            0.47; 95% confidence interval [CI], 0.37-0.59; =
<I>P</I>&lt;0.0001).=20
            A greater percentage of patients receiving FOLFIRINOX had a =
complete=20
            response, partial response or stable disease (70.2% vs. =
50.8%;=20
            <I>P</I>=3D0.0003); the response rate was higher in the =
FOLFIRINOX=20
            group (31.6% vs. 9.4%; <I>P</I>=3D0.0001).<B> </B></P>
            <P><IMG alt=3D"" hspace=3D7=20
            =
src=3D"http://www.clinicaloncology.com/aimages/2010/con0810_018_graphic_c=
300.jpg"=20
            align=3Dright vspace=3D7 border=3D0>Several grade 3/4 =
hematologic=20
            toxicities were more common in patients receiving FOLFIRINOX =

            including neutropenia (45.7% vs. 18.7%), febrile neutropenia =
(5.4%=20
            vs. 0.6%) and thrombocytopenia (9.1% vs. 2.4%) (Figure 2). =
One=20
            toxicity-related death occurred in each arm. Several =
nonhematologic=20
            grade 3/4 adverse events also were more frequent in patients =

            receiving FOLFIRINOX, including peripheral neuropathy (9% =
vs. 0),=20
            vomiting (14.5% vs. 4.7%), fatigue (23.2% vs. 14.2%), =
diarrhea=20
            (12.7% vs. 1.2%) and grade 2 alopecia (11.4% vs. 0.6%). In =
contrast,=20
            alanine aminotransferase elevations were more common in =
patients=20
            receiving gemcitabine (18.6% vs. 7.3%).</P>
            <P>=93FOLFIRINOX treatment results in a higher frequency of =
grade 3/4=20
            febrile neutropenia,=94 Dr. Conroy said. =93It=92s clear =
that we should=20
            select patients and explain the risk of febrile =
neutropenia.=94</P>
            <P></P></TD></TR>
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          <TD><STRONG>More solid tumors</STRONG></TD></TR>
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                  Combination Improves Survival in Pancreatic Cancer=20
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                  Improves Survival In Advanced Melanoma </A><BR><FONT=20
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                  Improves Survival in Metastatic Breast Cancer =
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2010</FONT> </TD></TR>
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                  Therapy and Radiation Is New Standard</A> <BR><FONT=20
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                  Agent Shows Impressive Activity in NSCLC </A><BR><FONT =

                  style=3D"FONT-SIZE: 9px" color=3D#333333>July, =
2010</FONT> </TD></TR>
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2010</FONT> </TD></TR>
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Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.clinicaloncology.com/jsfunction.js

<!--
// tool tip
function view(objthis)
{
        vthis =3D eval("sub" + objthis.id + ".style");
        vthis.visibility =3D "visible";
}
function hide(objthis)
{
        vthis =3D eval("sub" + objthis.id + ".style");
        vthis.visibility =3D "hidden";
}

// left nav var functions
function slide(Id, interval, to) {
var obj =3D document.getElementById(Id);
var H, step =3D 10;

if (obj =3D=3D null) return;
if (to =3D=3D undefined) { // user clicking
if (obj._slideStart =3D=3D true) return;
if (obj._expand =3D=3D true) {
to =3D 0;
obj.style.overflow =3D "hidden";
} else {
slide.addId(Id);
for(var i=3D0; i < slide.objects.length; i++) {
if (slide.objects[i].id !=3D Id && slide.objects[i]._expand =3D=3D true) =
{
slide(slide.objects[i].id);
}
}

obj.style.height =3D "";
obj.style.overflow =3D "";
obj.style.display =3D "block";
to =3D obj.offsetHeight;=20
obj.style.overflow =3D "hidden";
obj.style.height =3D "1px";
}
obj._slideStart =3D true;
}

step=A0=3D ((to > 0) ? 1:-1) * step;
interval=A0=3D ((interval=3D=3Dundefined)?1:interval);

obj.style.height =3D =
(H=3D((H=3D(isNaN(H=3DparseInt(obj.style.height))?0:H))+step<0)?0:H+step)=
+"px";


if (H <=3D 0) {
obj.style.display =3D "none";
obj.style.overflow =3D "hidden";
obj._expand =3D false;
obj._slideStart =3D false;
} else if (to > 0 && H >=3D to) {
obj.style.display =3D "block";
obj.style.overflow =3D "visible";
obj.style.height =3D H + "px";
obj._expand =3D true;
obj._slideStart =3D false;
} else {
setTimeout("slide('"+Id+"' , "+interval+", "+to+");", interval);
}
}
slide.objects =3D new Array();
slide.addId =3D function(Id)
{
for (var i=3D0; i < slide.objects.length; i++) {
if (slide.objects[i].id =3D=3D Id) return true;
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slide.objects[slide.objects.length] =3D document.getElementById(Id);
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// rollover image functions
function MM_swapImgRestore() { //v3.0
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function MM_preloadImages() { //v3.0
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d.MM_p[j++].src=3Da[i];}}
}

function MM_findObj(n, d) { //v4.01
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  for(i=3D0;!x&&d.layers&&i<d.layers.length;i++) =
x=3DMM_findObj(n,d.layers[i].document);
  if(!x && d.getElementById) x=3Dd.getElementById(n); return x;
}

function MM_swapImage() { //v3.0
  var i,j=3D0,x,a=3DMM_swapImage.arguments; document.MM_sr=3Dnew Array; =
for(i=3D0;i<(a.length-2);i+=3D3)
   if ((x=3DMM_findObj(a[i]))!=3Dnull){document.MM_sr[j++]=3Dx; =
if(!x.oSrc) x.oSrc=3Dx.src; x.src=3Da[i+2];}
}

// open new window function
function MM_openBrWindow(theURL,winName,features) { //v2.0
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// go to url function
function MM_goToURL() { //v3.0
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eval(args[i]+".location=3D'"+args[i+1]+"'");
}


// scrolling text functions
var Toggle =3D1; 		// scroller
function DWtop(chk)=20
{  =20
  Toggle =3D 0;  =20
  switch(chk) {=20
        case 1:=20
          pf.stop();=20
          break;=20
        case 2:=20
          pf.stop();=20
          break;=20
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function DWstart(chk)   // scroller
{  =20
  Toggle =3D 1;  =20
  switch(chk) {=20
        case 1:=20
          pf.start();=20
          break;=20
        case 2:=20
          pf.start();=20
          break;=20
  }    =20
}
//-->
------=_NextPart_000_0000_01CB3547.C27CF3B0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.clinicaloncology.com/include/wt_sdc_advtrack.js

<!-- START OF SDC Advanced Tracking Code -->
<!-- Copyright (c) 1996-2008 WebTrends Inc.  All rights reserved. -->
<!-- V8.0 -->
<!-- $DateTime: 2007/02/16 11:44:56 $ -->

var gService =3D false;
var gTimeZone =3D -5;
// Code section for Enable First-Party Cookie Tracking
function dcsCookie(){
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		dcsOther();
	}
	else if (typeof(dcsPlugin)=3D=3D"function"){
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	else if (typeof(dcsFPC)=3D=3D"function"){
		dcsFPC(gTimeZone);
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}
function dcsGetCookie(name){
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		var end=3Ddocument.cookie.indexOf(";",start);
		if (end=3D=3D-1){
			end=3Ddocument.cookie.length;
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		return unescape(document.cookie.substring(start,end));
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	return null;
}
function dcsGetCrumb(name,crumb){
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			return aCrumb[1];
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}
function dcsGetIdCrumb(name,crumb){
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	var id=3Dcookie.substring(0,cookie.indexOf(":lv=3D"));
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function dcsIsFpcSet(name,id,lv,ss){
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function dcsFPC(offset){
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	var dCur=3Dnew Date();
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	var dExp=3Dnew Date(dCur.getTime()+315360000000);
	var dSes=3Dnew Date(dCur.getTime());
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		WT.co_f=3Did;
		var dLst=3Dnew Date(lv);
		WT.vt_f_tlh=3DMath.floor((dLst.getTime()-adj)/1000);
		dSes.setTime(ss);
		if =
((dCur.getTime()>(dLst.getTime()+1800000))||(dCur.getTime()>(dSes.getTime=
()+28800000))){
			WT.vt_f_tlv=3DMath.floor((dSes.getTime()-adj)/1000);
			dSes.setTime(dCur.getTime());
			WT.vt_f_s=3D"1";
		}
		if =
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	WT.co_f=3Descape(WT.co_f);
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document.cookie=3Dname+"=3D"+"id=3D"+WT.co_f+":lv=3D"+dCur.getTime().toSt=
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// Code section for Use the WebTrends Cookie Plug-in cookie. Your web =
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function dcsPlugin(){
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		else if (dcsGetCookie(gFpc)){
			document.cookie=3DgFpc+"=3D; expires=3DThu, 01-Jan-1970 00:00:01 =
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	}
	else if (dcsGetCookie("WEBTRENDS_ID")){
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}

function dcsAdv(){
	dcsFunc("dcsET");
	dcsFunc("dcsCookie");
	dcsFunc("dcsAdSearch");
	dcsFunc("dcsTP");
}

//-->

------=_NextPart_000_0000_01CB3547.C27CF3B0
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.clinicaloncology.com/include/wt_sdc_tag.js

<!-- START OF SmartSource Data Collector TAG -->
<!-- Copyright (c) 1996-2008 WebTrends Inc.  All rights reserved. -->
<!-- V8.0 -->
<!-- $DateTime: 2007/03/01 14:48:29 $ -->

var gDomain=3D"webtrends.mcmahonmed.com";
var gDcsId=3D"dcsj5wcm7ng8dvs6irzldmnqv_9e1p";


if =
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	document.write("<SCR"+"IPT TYPE=3D'text/javascript' =
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var gImages=3Dnew Array;
var gIndex=3D0;
var DCS=3Dnew Object();
var WT=3Dnew Object();
var DCSext=3Dnew Object();
var gQP=3Dnew Array();
var gI18n=3Dfalse;
if (window.RegExp){
	var RE=3DgI18n?{"%25":/\%/g}:{"%09":/\t/g,"%20":/ =
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g,"%7F":/\x7F/g,"%A0":/\xA0/g};
	if (gI18n){
		var =
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// Add customizations here

function dcsVar(){
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	WT.bh=3DdCurrent.getHours();
	=
WT.ul=3Dnavigator.appName=3D=3D"Netscape"?navigator.language:navigator.us=
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	if (typeof(screen)=3D=3D"object"){
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WT.cd=3Dnavigator.appName=3D=3D"Netscape"?screen.pixelDepth:screen.colorD=
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		WT.sr=3Dscreen.width+"x"+screen.height;
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	if (typeof(navigator.javaEnabled())=3D=3D"boolean"){
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	if (document.title){
		WT.ti=3Ddocument.title;
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	WT.js=3D"Yes";
	WT.jv=3DdcsJV();
	if (document.body&&document.body.addBehavior){
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		WT.ct=3Ddocument.body.connectionType||"unknown";
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		WT.hp=3Ddocument.body.isHomePage(location.href)?"1":"0";
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	else{
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	if (parseInt(navigator.appVersion)>3){
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	DCS.dcsdat=3DdCurrent.getTime();
	DCS.dcssip=3Dwindow.location.hostname;
	DCS.dcsuri=3Dwindow.location.pathname;
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function dcsA(N,V){
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function dcsEscape(S, REL){
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function dcsEncode(S){
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function dcsCreateImage(dcsSrc){
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}

function dcsMeta(){
	var elems;
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function dcsTag(){
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	var =
P=3D"http"+(window.location.protocol.indexOf('https:')=3D=3D0?'s':'')+":/=
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	var keys=3D["co_f","vt_sid","vt_f_tlv"];
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	for (N in WT){
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}

function dcsJV(){
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	var ff10=3D(agt.indexOf("firefox/1.0")!=3D-1);
	var ff15=3D(agt.indexOf("firefox/1.5")!=3D-1);
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via"},b_title=3D{email:"Email",mailto:"Email",print:"Print",favorites:"Sa=
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nosend=3D{feed:1,more:1,email:1,mailto:1},nowindow=3D{feed:1,email:1,mail=
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l=3Dr.length;for(var i=3D0;i<l;i++){for(var =
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lt;img.src=3Durl;return =
img},_parseThirdPartyAttributes=3Dfunction(el,prefix){var =
key,attr=3D[],rv=3D{};for(var =
i=3D0;i<el.attributes.length;i++){key=3Del.attributes[i];attr=3Dkey.name.=
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acs=3D(conf||{}).services_custom;if(!acs){return}if(!(acs instanceof =
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service=3Dacs[i];if(service.name&&service.icon&&service.url){service.code=
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rv=3D{conf:config||{},share:share||{}};rv.conf=3D_parseAttributes(el,conf=
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{};attrs=3Dattrs||{};var =
config=3Dconf.conf||globalConfig,share=3Dconf.share||globalShare,onmouseo=
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addthis_open(el,ss,s.url,s.title,rpl(config,upConfig),s)}:nowindow[ss]?fu=
nction(el,config,share){var s=3Drpl(share,upShare);return =
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{if(!attrs.nohover){if(onmouseover=3D=3D=3Du){onmouseover=3Dfunction(el,c=
onfig,share){return =
addthis_open(el,"",null,null,config,share)}}if(onmouseout=3D=3D=3Du){onmo=
useout=3Dfunction(el){return =
addthis_close()}}if(onclick=3D=3D=3Du){onclick=3Dfunction(el,config,share=
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addthis_sendto("more",config,share)}}}else{if(onclick=3D=3D=3Du){onclick=3D=
function(el,config,share){return =
addthis_open(el,"more",null,null,config,share)}}}}}what=3D_select(what);f=
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o=3Dwhat[i],oattr=3D_getATtributes(o,config,share,true)||{};mrg(oattr.con=
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customService=3D_getCustomService(ss,o.conf);if(customService&&customServ=
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url=3Do.share.url||addthis_share.url;if(attrs.follow){o.href=3Durl;o.oncl=
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children.length=3D=3D1&&o.parentNode&&o.parentNode.className.indexOf("too=
lbox")>-1){var =
sp=3Dd.ce("span");sp.className=3D"addthis_follow_label";sp.innerHTML=3Dad=
dthis.util.getServiceName(ss);o.appendChild(sp)}}else{o.href=3D_ate.share=
.genurl(ss,0,o.share,o.conf)}addEvents(o,ss,url);o.target=3D"_blank";addt=
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use_mailto||_ate.bro.iph||_ate.bro.ipa))){o.onclick=3Dfunction(){(new =
Image()).src=3D_ate.share.genurl("mailto",0,o.share,o.config)};o.href=3Dg=
enieu(o.share);addEvents(o,ss,url);addthis.ems.push(o)}}if(!o.title||o.at=
_titled){o.title=3Dunaccent((attrs.follow?(f_title[ss]?f_title[ss]:"Follo=
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"))+addthis.util.getServiceName(ss,!customService));o.at_titled=3D1}}else=
{if(o.conf.product&&o.parentNode.className.indexOf("toolbox")=3D=3D-1){re=
gisterProductCode(o)}}}var =
app;switch(internal){case"img":if(!o.hasChildNodes()){var =
lang=3D(o.conf.ui_language||_ate.lng()).split("-").shift(),validatedLang=3D=
_ate.ivl(lang);if(!validatedLang){lang=3D"en"}else{if(validatedLang!=3D=3D=
1){lang=3DvalidatedLang}}app=3D_makeButton(_ate.iwb(lang)?150:125,16,"Sha=
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{o.appendChild(app)}}}},buttons=3Daddthis._gebcn(body,"A","addthis_button=
_",true,true),_renderToolbox=3Dfunction(collection,config,share,reprocess=
){for(var i=3D0;i<collection.length;i++){var =
b=3Dcollection[i];if(b=3D=3Dnull){continue}if(reprocess!=3D=3Dfalse||!b.o=
st){var =
attr=3D_getATtributes(b,config,share,true),hc=3D0,a=3D"at300",c=3Db.class=
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,options=3D{},sv=3Ds&&s.length?s[1]:0;mrg(attr.conf,globalConfig);mrg(att=
r.share,globalShare);if(sv){if(sv=3D=3D=3D"tweetmeme"){var =
tm_attr=3D_parseThirdPartyAttributes(b,"tm"),tmw=3D50,tmh=3D61;passthroug=
h=3D_ate.util.toKV(tm_attr);if(tm_attr.style=3D=3D=3D"compact"){tmw=3D95;=
tmh=3D25}b.innerHTML=3D'<iframe frameborder=3D"0" width=3D"'+tmw+'" =
height=3D"'+tmh+'" scrolling=3D"no" allowTransparency=3D"true" =
scrollbars=3D"no"'+(_ate.bro.ie6?" =
src=3D\"javascript:''\"":"")+"></iframe>";var =
tm=3Db.firstChild;tm.src=3D"//api.tweetmeme.com/button.js?url=3D"+_euc(at=
tr.share.url)+"&"+passthrough}else{if(sv=3D=3D=3D"facebook_like"){var =
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scrollbars=3D"no"'+(_ate.bro.ie6?" =
src=3D\"javascript:''\"":"")+"></iframe>";fblike=3Db.firstChild}fblike.st=
yle.overflow=3D"hidden";fblike.style.border=3D"none";fblike.style.borderW=
idth=3D"0px";fblike.style.width=3D"82px";fblike.style.height=3D"25px";fbl=
ike.style.marginTop=3D"-2px";fblike.src=3D"//www.facebook.com/plugins/lik=
e.php?href=3D"+_euc(attr.share.url)+"&layout=3Dbutton_count&show_faces=3D=
false&width=3D100&action=3Dlike&font=3Darial&"+passthrough;if(!_ate.bro.m=
si){b.appendChild(fblike)}}else{if(sv.indexOf("preferred")>-1){if(b._iss)=
{continue}registerProductCode(b);s=3Dc.match(/addthis_button_preferred_([=
0-9]+)(?:\s|$)/);var =
svidx=3D((s&&s.length)?Math.min(12,Math.max(1,parseInt(s[1]))):1)-1;if(wi=
ndow._atw){if(!b.parentNode.services){b.parentNode.services=3D{}}var =
excl=3D_atw.conf.services_exclude,locopts=3D_atw.loc,parentServices=3Db.p=
arentNode.services,opts=3D_uniquify(addthis_options.replace(",more","").s=
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ndexOf(sv)>-1||parentServices[sv])&&svidx<opts.length);if(parentServices[=
sv]){for(var k in =
_atw.list){if(!parentServices[k]&&excl.indexOf(k)=3D=3D-1){sv=3Dk;break}}=
}b._ips=3D1;if(b.className.indexOf(sv)=3D=3D-1){b.className+=3D" =
addthis_button_"+sv;b._iss=3D1}b.parentNode.services[sv]=3D1}else{_ate.al=
g(attr.conf.ui_language||window.addthis_language);_ate.plo.unshift(["deco=
",_renderToolbox,[b],config,share,true]);if(_ate.gssh){_ate.pld=3D_ate.aj=
s("static/r07/menu58.js")}else{if(!_ate.pld){_ate.pld=3D1;var =
loadmenu=3Dfunction(){_ate.pld=3D_ate.ajs("static/r07/menu58.js")};if(_at=
e.upm){_ate._rec.push(function(data){if(data.ssh){loadmenu()}});_ate.sto(=
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){sv=3Dsv.split("_follow").shift();options.follow=3Dtrue;attr.share.url=3D=
getFollowUrl(sv,attr.share.userid)}}}}if(!b.childNodes.length){var =
sp=3Dd.ce("span");b.appendChild(sp);sp.className=3Da+"bs =
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cn=3Db.childNodes[0];if(cn.nodeType=3D=3D3){var =
sp=3Dd.ce("span"),tv=3Dcn.nodeValue;b.insertBefore(sp,cn);sp.className=3D=
a+"bs =
at15t_"+sv}}else{hc=3D1}}if(sv=3D=3D=3D"compact"){if(!hc&&c.indexOf(a)=3D=
=3D-1){b.className+=3D" =
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if(sv=3D=3D=3D"expanded"){if(!hc&&c.indexOf(a)=3D=3D-1){b.className+=3D" =
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s.nohover=3Dtrue;options.singleservice=3D"more"}else{if((b.parentNode.cla=
ssName||"").indexOf("toolbox")>-1){if(!b.parentNode.services){b.parentNod=
e.services=3D{}}b.parentNode.services[sv]=3D1}if(!hc&&c.indexOf(a)=3D=3D-=
1){b.className+=3D" =
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r([b],attr,options);b.ost=3D1;registerProductCode(b)}}}},gat=3Dfunction(s=
,au,conf,share){var =
pageTracker=3Dconf.data_ga_tracker,propertyId=3Dconf.data_ga_property;if(=
propertyId&&typeof(window._gat)=3D=3D"object"){pageTracker=3D_gat._getTra=
cker(propertyId)}if(pageTracker&&typeof(pageTracker)=3D=3D"string"){pageT=
racker=3Dwindow[pageTracker]}if(pageTracker&&typeof(pageTracker)=3D=3D"ob=
ject"){var =
gaUrl=3Dau||(share||{}).url||location.href;if(gaUrl.toLowerCase().replace=
("https","http").indexOf("http%3a%2f%2f")=3D=3D0){gaUrl=3D_duc(gaUrl)}try=
{pageTracker._trackEvent("addthis",s,gaUrl)}catch(e){try{pageTracker._ini=
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=3Dgat;addthis.update=3Dfunction(which,what,value){if(which=3D=3D"share")=
{if(!window.addthis_share){window.addthis_share=3D{}}window.addthis_share=
[what]=3Dvalue;upShare[what]=3Dvalue;for(var i in addthis.links){var =
o=3Daddthis.links[i],rx=3Dnew =
RegExp("&"+what+"=3D(.*)&"),ns=3D"&"+what+"=3D"+_euc(value)+"&";o.href=3D=
o.href.replace(rx,ns);if(o.href.indexOf(what)=3D=3D-1){o.href+=3Dns}}for(=
var i in addthis.ems){var =
o=3Daddthis.ems[i];o.href=3Dgenieu(addthis_share)}}else{if(which=3D=3D"co=
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is_config[what]=3Dvalue;upConfig[what]=3Dvalue}}};addthis._render=3D_rend=
er;var rsrcs=3D[new =
_ate.resource.Resource("countercss",_atr+"static/r07/counter41.css",funct=
ion(){return true}),new =
_ate.resource.Resource("counter",_atr+"js/250/plugin.sharecounter.js",fun=
ction(){return =
window.addthis.counter.ost})];if(!w.JSON||!w.JSON.stringify){rsrcs.unshif=
t(new =
_ate.resource.Resource("json2",_atr+"static/r07/json2.js",function(){retu=
rn =
w.JSON&&w.JSON.stringify}))}addthis.counter=3Dfunction(what,config,share)=
{if(what){what=3Daddthis._select(what);if(what.length){for(var k in =
rsrcs){rsrcs[k].load()}}}};addthis.button=3Dfunction(what,config,share){c=
onfig=3Dconfig||{};if(!config.product){config.product=3D"men-"+_atc.ver}_=
render(what,{conf:config,share:share},{internal:"img"})};addthis.toolbox=3D=
function(what,config,share){var toolboxes=3D_select(what);for(var =
i=3D0;i<toolboxes.length;i++){var =
tb=3Dtoolboxes[i],attr=3D_getATtributes(tb,config,share),sp=3Dd.ce("div")=
,c;if(!attr.conf.product){attr.conf.product=3D"tbx"+(tb.className.indexOf=
("32x32")>-1?"32":"")+"-"+_atc.ver}if(tb){c=3Dtb.getElementsByTagName("a"=
);if(c){_renderToolbox(c,attr.conf,attr.share)}tb.appendChild(sp)}sp.clas=
sName=3D"atclear"}};addthis.ready=3Dfunction(){var =
at=3Daddthis,a=3D".addthis_";if(at.ost){return}at.ost=3D1;addthis.toolbox=
(a+"toolbox");addthis.button(a+"button");addthis.counter(a+"counter");_re=
nderToolbox(buttons,null,null,false);_ate.ed.fire("addthis.ready",addthis=
);for(var =
i=3D0,plo=3Dat.plo,q;i<plo.length;i++){q=3Dplo[i];(q.ns?at[q.ns]:at)[q.ca=
ll].apply(this,q.args)}};addthis.util.getAttributes=3D_getATtributes;wind=
ow.addthis=3Daddthis;window.addthis.ready()}}));_ate.extend(addthis,{user=
:(function(){var f=3D_ate,c=3Daddthis,g=3D{},d=3D0,j;function =
i(a,k){return f.reduce(["getID","getServiceShareHistory"],a,k)}function =
h(a,k){return function(l){setTimeout(function(){l(f[a]||k)},0)}}function =
b(){if(d){return}if(j!=3D=3Dnull){clearTimeout(j)}j=3Dnull;d=3D1;i(functi=
on(l,a,k){g[a]=3Dg[a].queuer.flush(h.apply(c,l[k]),c);return =
l},[["uid",""],["_ssh",[]]])}f._rec.push(b);j=3DsetTimeout(b,5000);g.getP=
referredServices=3Dfunction(a){if(window._atw){a(addthis_options.split(",=
"))}else{f.plo.push(["pref",a]);_ate.alg();if(f.gssh){f.pld=3Df.ajs("stat=
ic/r07/menu58.js")}else{if(!f.pld){f.pld=3D1;_ate._rec.push(function(k){i=
f(k.ssh){_ate.pld=3D_ate.ajs("static/r07/menu58.js")}})}}}};return =
i(function(k,a){k[a]=3D(new c._Queuer(a)).call;return k},g)})()});
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