From: Subject: Marijuana derivative could be useful for pain treatment Date: Fri, 6 Aug 2010 16:01:15 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0091_01CB3580.9935B170" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0091_01CB3580.9935B170 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencedaily.com/releases/2010/07/100707222548.htm Marijuana = derivative could be useful for pain treatment

Marijuana Derivative Could Be Useful for = Pain=20 Treatment

ScienceDaily (July 10, 2010) =97 = A new=20 compound similar to the active component of marijuana (cannabis) might = provide=20 effective pain relief without the mental and physical side effects of = cannabis,=20 according to a study in the July issue of Anesthesia & = Analgesia,=20 official journal of the International Anesthesia Research Society = (IARS).

The synthetic cannabinoid (cannabis-related) compound, called MDA19, = seems to=20 avoid side effects by acting mainly on one specific subtype of the = cannabinoid=20 receptor. "MDA19 has the potential for alleviating neuropathic pain = without=20 producing adverse effects in the central nervous system," according to = the study=20 by Dr Mohamed Naguib of The University of Texas M.D. Anderson Cancer = Center.

MDA19 Works on a Single Cannabinoid Receptor

The researchers performed a series of experiments to analyze the = pharmacology=20 and effects of the synthetic cannabinoid MDA19. There are two subtypes = of the=20 cannabinoid chemical receptor: CB1, found mainly in the brain; and CB2, = found=20 mainly in the peripheral immune system. Dr. Naguib's group has been = doing=20 research to see if the cannabinoid receptors -- particularly CB2 -- can = be a=20 useful target for new drugs to treat neuropathic pain. Neuropathic pain = is a=20 difficult-to-treat type of pain caused by nerve damage, common in = patients with=20 trauma, diabetes, and other conditions.

MDA19 was designed to have a much stronger effect on the CB2 receptor = than on=20 the CB1 receptor. In humans, MDA19 showed four times greater activity on = the CB2=20 receptor than on the CB1 receptor. In rats, the difference was even = greater. The=20 experiments also showed that MDA19 had "protean" effects, so-called = after the=20 shape-shifting Greek sea god Proteus -- under different conditions, it = could=20 either block or activate the cannabinoid receptors.

In rats, treatment with MDA19 effectively reduced specific types of=20 neuropathic pain, with greater effects at higher doses. At the same = time, it did=20 not seem to cause any of the behavioral effects associated with = marijuana.

Potential to Develop Effective Pain Drugs that Avoid Side Effects The = "functional selectivity" of MDA19 -- the fact that it acts mainly on the = CB2=20 receptor and has a range of effects under differing conditions -- could = have=20 important implications for drug development. "[W]ith functionally = selective=20 drugs, it would be possible to separate the desired from the undesired = effects=20 of a single molecule through a single receptor," Dr. Naguib and = colleagues=20 write.

This means that MDA19 could be a promising step toward developing = medications=20 that have the pain-reducing effect of cannabinoids while avoiding the = mental and=20 physical side effects of marijuana itself. However, more research will = be needed=20 before MDA19 or other agents that act on the CB2 receptor are ready for = testing=20 in humans.

"These elegant studies by Professor Naguib demonstrate remarkable = analgesic=20 properties for this synthetic cannabinoid," comments Dr. Steven L. = Shafer of=20 Columbia University, Editor-in-Chief of Anesthesia &Analgesia. "The = studies=20 suggest a novel mechanism for this protean agonist. Although = preliminary, these=20 studies suggest that synthetic cannabinoids may be significant step = forward for=20 patients suffering from neuropathic pain."

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The above story is reprinted (with editorial adaptations by=20 ScienceDaily staff) from materials provided by International Anesthesia = Research Society=20 (IARS), via Newswise.

Journal Reference:

  • Jijun J. Xu et al. Pharmacological Characterization of a = Novel=20 Cannabinoid Ligand, MDA19, for Treatment of Neuropathic Pain. = Anesthesia & Analgesia, July 2010 vol. 111 no. 1 99-109 = [link]
    • =20
    APA

    MLA =

    Note: If no author is given, the source is cited=20 instead.

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PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } #googletop { FONT-SIZE: 13px; MARGIN: 0px 0px 10px } #googletop DIV { OVERFLOW: hidden } #googletop DIV.left { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; FLOAT: left; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #googletop DIV.right { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px; TEXT-ALIGN: right } #googletop DIV.clear { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } #googletop DIV.col1 { PADDING-RIGHT: 5px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 5px; WIDTH: 164px; PADDING-TOP: 5px } #googletop DIV.col2 { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FLOAT: left; PADDING-BOTTOM: = 5px; WIDTH: 164px; PADDING-TOP: 5px } #googletop DIV.col3 { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; FLOAT: right; PADDING-BOTTOM: = 5px; WIDTH: 164px; PADDING-TOP: 5px } #googleend { FONT-SIZE: 13px; MARGIN: 0px 0px 10px } #googleend DIV { OVERFLOW: hidden } 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