From: Subject: New method helps nerves grow after trauma or injury Date: Wed, 14 Jul 2010 16:16:04 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01CB236F.DBBD4F30" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01CB236F.DBBD4F30 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencedaily.com/releases/2010/07/100712102802.htm New method = helps nerves grow after trauma or injury

New Method Helps Nerves Grow After = Trauma or=20 Injury

ScienceDaily (July 12, 2010) =97 = University of=20 Calgary scientists have discovered a way to enhance nerve regeneration = in the=20 peripheral nervous system. The finding could lead to new treatments for = nerve=20 damage caused by diabetes or traumatic injuries. Peripheral nerves = connect the=20 brain and spinal cord to the body, and without them, there is no = movement or=20 sensation. Peripheral nerve damage is common and often irreversible.

The research is published in the July 7, 2010 edition of the = Journal of=20 Neuroscience.

Senior researcher on the study, Dr. Douglas Zochodne, is a = neurologist and=20 professor in the Department of Clinical Neurosciences. Kimberly = Christie, lead=20 author on the study and a PhD student in Dr. Zochodne's lab, along with=20 Hotchkiss Brain Institute colleagues, used a rat model to examine a = pathway that=20 helps nerves to grow and survive. Within this pathway is a molecular = brake,=20 called PTEN, that helps to prevent excessive cell growth under normal=20 conditions.

In addition to discovering for the first time that PTEN is found in = the=20 peripheral nervous system, Zochodne's team demonstrated that following = nerve=20 injury, PTEN prevents peripheral nerves from regenerating. The team was = able to=20 block PTEN, an approach that dramatically increased nerve outgrowth.

Kimberly Christie says, "We were amazed to see such a dramatic effect = over=20 such a short time period. No one knew that nerves in the peripheral = system could=20 regenerate in this way, nerves that can be damaged if someone has = diabetes for=20 example. This finding could eventually help people who have lost feeling = or=20 motor skills recover and live with less pain."

Peripheral nerve damage can lead to pain, tingling, numbness or = difficulty=20 coordinating hands, feet, arms or legs. This can happen with diseases = like=20 diabetes, an injury due to a crushed or cut nerve, or other conditions = known as=20 neuropathy.

"Removing the brakes on regeneration offers us a new approach. Our = next steps=20 will be to find out if the exciting rise in nerve outgrowth we have = observed=20 will result in long term benefits," says Zochodne.

This research was supported by the Canadian Institutes of Health = Research,=20 Alberta Innovates -- Health Solutions (funded by the Alberta Heritage = Foundation=20 for Medical Research Endowment Fund) and the National Science and = Engineering=20 Research Council.

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The above story is reprinted (with editorial adaptations by=20 ScienceDaily staff) from materials provided by University=20 of Calgary, via EurekAlert!, a service of AAAS.

Journal Reference:

  • Kimberly J. Christie, Christine A. Webber, Jose A. Martinez, = Bhagat Singh,=20 and Douglas W. Zochodne. PTEN Inhibition to Facilitate = Intrinsic=20 Regenerative Outgrowth of Adult Peripheral Axons. Journal = of=20 Neuroscience, 2010; DOI: 10.1523/JNEUROSCI.6271-09.2010
    • =20
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    Note: If no author is given, the source is cited=20 instead.

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PADDING-LEFT: 10px; FONT-WEIGHT: bold; FONT-SIZE: 13px; = BACKGROUND: #eee; FLOAT: left; PADDING-BOTTOM: 2px; BORDER-LEFT: #999 = 1px solid; COLOR: #009; LINE-HEIGHT: 17px; MARGIN-RIGHT: 8px; = PADDING-TOP: 2px; BORDER-BOTTOM: #999 1px solid; TEXT-DECORATION: none } #tablist A:hover { BACKGROUND: #fff; COLOR: #900 } #tablist LI A.activetab { BACKGROUND: #fff; COLOR: #900; BORDER-BOTTOM: #fff 1px solid } #tablist UL A:hover { BACKGROUND: #fff; COLOR: #900! important } #tabcontainer { CLEAR: both; BORDER-RIGHT: #999 1px solid; PADDING-RIGHT: 10px; = BORDER-TOP: #999 1px; PADDING-LEFT: 10px; BACKGROUND: #fff; = PADDING-BOTTOM: 10px; MARGIN: 0px; BORDER-LEFT: #999 1px solid; = PADDING-TOP: 10px; BORDER-BOTTOM: #999 1px solid } H1 { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 18px; PADDING-BOTTOM: = 0px; MARGIN: 0px; COLOR: #900; PADDING-TOP: 0px } H1.moreleft { FLOAT: left; MARGIN-BOTTOM: -3px; COLOR: #000 } H1.story { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 20px; 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PADDING-LEFT: 0px; FONT-SIZE: 11px; FLOAT: left; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #googleleft DIV.right { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px; TEXT-ALIGN: right } #googleleft DIV.clear { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } #googlesearch { PADDING-RIGHT: 0px; PADDING-LEFT: 10px; FONT-SIZE: 13px; FLOAT: right; = PADDING-BOTTOM: 10px; OVERFLOW: hidden; WIDTH: 175px; PADDING-TOP: 10px } #googlesearch DIV { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googlesearch DIV.left { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; FLOAT: left; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #googlesearch DIV.right { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px; TEXT-ALIGN: right } #googlesearch DIV.clear { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } #googlehome { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; FONT-SIZE: 13px; = PADDING-BOTTOM: 10px; OVERFLOW: hidden; WIDTH: 180px; PADDING-TOP: 5px } #googlehome DIV { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googlehome DIV.left { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; FLOAT: left; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #googlehome DIV.right { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px; TEXT-ALIGN: right } #googlehome DIV.clear { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } #googletop { FONT-SIZE: 13px; MARGIN: 0px 0px 10px } #googletop DIV { OVERFLOW: hidden } #googletop DIV.left { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; FLOAT: left; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #googletop DIV.right { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px; TEXT-ALIGN: right } #googletop DIV.clear { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px } #googletop DIV.col1 { PADDING-RIGHT: 5px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 5px; WIDTH: 164px; PADDING-TOP: 5px } #googletop DIV.col2 { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FLOAT: left; PADDING-BOTTOM: = 5px; WIDTH: 164px; PADDING-TOP: 5px } #googletop DIV.col3 { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; FLOAT: right; PADDING-BOTTOM: = 5px; WIDTH: 164px; PADDING-TOP: 5px } #googleend { FONT-SIZE: 13px; MARGIN: 0px 0px 10px } #googleend DIV { OVERFLOW: hidden } #googleend DIV.left { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; FLOAT: left; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #googleend DIV.right { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 11px; PADDING-BOTTOM: = 0px; PADDING-TOP: 0px; TEXT-ALIGN: right } #googleend DIV.clear { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 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PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 5px; WIDTH: 210px; PADDING-TOP: 5px } #googlebottom DIV.col2 { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FLOAT: left; PADDING-BOTTOM: = 5px; WIDTH: 220px; PADDING-TOP: 5px } #googlebottom DIV.col3 { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; FLOAT: right; PADDING-BOTTOM: = 5px; WIDTH: 210px; PADDING-TOP: 5px } #share_form { BORDER-RIGHT: #999 1px solid; BORDER-TOP: #999 1px solid; DISPLAY: = none; Z-INDEX: 999; BACKGROUND: #eee; BORDER-LEFT: #999 1px solid; = WIDTH: 300px; BORDER-BOTTOM: #999 1px solid; POSITION: absolute } #share_title { FLOAT: left; MARGIN: 5px; WIDTH: 60% } #share_close { FLOAT: right; MARGIN: 5px; FONT-STYLE: italic } #share_close A { COLOR: #009; TEXT-DECORATION: none } #share_close A:hover { COLOR: #900; TEXT-DECORATION: none } #share_form DIV.clear { CLEAR: both; FLOAT: none } #share_social { PADDING-RIGHT: 10px; PADDING-LEFT: 7px; BACKGROUND: #fff; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px } #share_social UL { 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