Alpha-2 Adrenergic Agonists

There are two alpha-2-adrenergic agonists that have some evidence as pain relievers: tizanidine (Zanaflex®) and clonidine (Catapres®). There are some studies showing that tizanidine can be effective for tension-type headache, back pain, neuropathic pain and myofascial pains. Clonidine has been used to treat neuropathic pain that is not responding to other treatment or therapy.