May 2012

Pfizer Stops Phase 3 Trial of Lyrica Capsules CV in Neuropathic Pain Associated with HIV Neuropathy

Pfizer announced that it has stopped a Phase 3 clinical trail of Lyrica for patients with HIV neuropathy based on an interim analysis of the results. “The results of this study show the complexities of studying pain, particularly in a difficult-to-treat condition such as neuropathic pain associated with HIV neuropathy for which there are no …

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Early Axonal Dysfunction Precedes Diabetic Neuropathy

Researchers at Wan Fang Hospital in Taipei, Taiwan, have conducted a study to determine if early axonal dysfunction can be detected prior to the onset of diabetic peripheral neuropathy. Dr. Jia-Ying Sung and colleagues found that patients with type 2 diabetes but no clinical symptoms of neuropathy displayed changes in excitability parameters of the nerves …

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Yale Team Discovers Unexpected Source of Diabetic Neuropathic Pain

Researchers from Yale and the West Haven Veterans Affairs Medical Center have published findings in the Journal of Neuroscience describing how changes in the structure of dendritic spines are associated with pain in laboratory rats with diabetes. Dendritic spines are microscopic projections on the receiving branches of nerve calls. This study “reveals that these dendritic …

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Phase 3 Data Show NUCYNTA® ER Extended-Release Tablets Provide Pain Relief Management

Janssen Pharmaceuticals, Inc. presented results at the 31st Annual Scientific Meeting of the American Pain Society suggesting these extended-release tablets were significantly more effective than placebo in providing pain management among adults with chronic moderate to severe, painful diabetic peripheral neuropathy. “Painful DPN is a common and burdensome complication of diabetes, and controlling pain in …

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