May 2013

Comparative Efficacy of Oral Pharmaceuticals for the Treatment of Chronic Peripheral Neuropathic Pain

The goal of this study was to assess the efficacy of oral medications on chronic peripheral neuropathy since studies typically report of short-duration outcomes and fail to account for medication tolerability. Seventeen studies were compared and results found that pregabalin and duloxetine had the highest beneficial effects for chronic neuropathic pain.  READ MORE Source: Pain Medicine

Duloxetine and Pregabalin: High-dose monotherapy or their combination?

Duloxetine (ie, Cymbalta, and others) and pregabalin (ie, Lyrica) are used in the first line of treatment for diabetic peripheral neuropathy but have been shown to provide any relief in only about 40% of the patients. This study was focused on whether a combination therapy of duloxetine and pregabilin at standard doses may provide better pain …

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Painful and Painless Diabetic Peripheral Neuropathy: One Disease or Two?

Researchers in Endocrinology at the university of Tor Vergata, Rome, published a review of available literature  dealing with the similarities and differences between painful and painless DPN to try and determine if whether they are the same disease. Some people develop an ‘insensate’ variety of DPN while others experience distressing pain.  READ MORE Source: Curr Diab Rep

Nutraceuticals and Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Systematic Review

A team of researchers at Queensland, School of Medicine, reviewed 24 studies to determine if nutraceuticals (i.e., vitamin E, acetyl-L-carnitine, glutamine, glutathione, alpha lipoic acid, magnesium, and others) are effective in reducing the peripheral neuropathy side effect in patients who have received chemotherapy treatments. The studies were mixed and currently no agent has shown solid …

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