August 2013

Equivalency of Tricyclic Antidepressants in Open-Label Neuropathic Pain Study

Researchers from the Department of Clinical Neurosciences, the Hotchkiss Brain Institute, and the University of Calgary, just published results of a study to compare adverse effects, tolerability and efficacy of the tricyclic antidepressants (TCAs) amitriptyline and nortriptyline in management of neuropathic pain due to peripheral neuropathy (PN). Their results show that amitriptyline and nortriptyline are …

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Voltage Gated Sodium and Calcium Channel Blockers for the Treatment of Chronic Inflammatory Pain

Inflammation associated with chronic pain states is deleterious to health and often debilitating for the patient. It has been hypothesized that pain of inflammatory origin may evolve into a condition that resembles neuropathic pain. This review by researchers from the Department of Neuroscience, Physiology and Pharmacology, University College London considers the therapeutic potential for sodium …

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