June 2014

Neuromodulatory Treatments for Chronic Pain: Efficacy and Mechanisms

Chronic pain is common, and the available treatments do not provide adequate relief for most patients. Neuromodulatory interventions that modify brain processes underlying the experience of pain have the potential to provide substantial relief for some of these patients. The purpose of this Review is to summarize the state of knowledge regarding the efficacy and …

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A Skin Cream for Peripheral Neuropathy? Small Molecule May go a Long Way

About half of people with diabetes develop peripheral neuropathy. While there are some treatments to reduce pain, there’s nothing that restores sensation. Gabriel Corfas, PhD, of the F.M. Kirby Neurobiology Center at Boston Children’s Hospital, wondered if replenishing a growth factor called GDNF (short for glial-derived neurotrophic factor) could improve sensory neurons’ health and function. …

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Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

Chemotherapy-induced peripheral neuropathy (CIPN) is a common treatment-related adverse effect and affects long-term quality of life.1 It has the potential to result in chemotherapy dose reductions and/or early discontinuation.The purpose of this study is to provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult …

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Rodent Models of Chemotherapy-Induced Peripheral Neuropathy

A common complication of chemotherapy is neurotoxicity that often manifests itself as peripheral neuropathy. Many cancer drugs can cause chemotherapy-induced peripheral neuropathy (CIPN), and the incidence can be up to 90%. A significant percentage of patients improve once the offending drug is stopped, but as much as 50% of the affected individuals are left with …

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