A new study led by researchers at McGill University in Canada recently revealed that peripheral neuropathy is associated with a mitochondrial dysfunction and a bioenergetic impairment. Mitochondria are small cellular organelles in the body responsible for the production of energy through the process of respiration. Mitochondria dysfunction can impair the cellular energy metabolism, affecting several organs and cells, like neurons, potentially leading to cell death and neurodegeneration. Mitochondrial dysfunction has been observed in models of chemotherapy induced neuropathy, diabetic neuropathy, and in HIV-associated sensory neuropathy. Furthermore, in humans, mutations in mitochondrial genes frequently result in the development of painful peripheral neuropathy, as seen in patients with Charcot-Marie-Tooth disease. READ MORE
Source: Mitochondrial Disease News