Chronic kidney or renal failure (uremia) occurs when the kidneys gradually fail to function properly. When the kidneys are impaired, fluids and waste products accumulate in the body. In some cases, kidney failure may cause peripheral neuropathy .
Many conditions can cause kidney failure; the most common are diabetes  and high blood pressure.
Since many organs and systems within the body are affected by kidney failure and fluid retention, kidney failure causes a general state of ill health. Also, many complications may occur, including uremic neuropathy—a type of peripheral neuropathy that progresses slowly and may afflict 20% to 50% of people with kidney disease.
Uremic Neuropathy Symptoms
(Not all symptoms and signs may be present.)
Symptoms of uremic neuropathy include:
- Pain, numbness, and tingling in the feet and legs
- Feeling of “pins and needles”
- Cramps, muscle twitches, or increased pain sensation in the feet and legs
- Muscle weakness or reduced sensation may occur
Tests for Uremic Neuropathy
(Not all evaluations and tests may be necessary.)
- Neurological exam 
- Electromyography 
- Nerve conduction velocity test 
- Blood tests including tests for renal function
Uremic Neuropathy Treatment
(Not all treatments and therapies may be indicated.)
For relief of uremic neuropathy:
- Kidney transplant
- Take safety measures to compensate for loss of sensation