2021 PRMRP Awarded Projects

In 2020, Congress for the first time included “peripheral neuropathy” as an eligible condition for study through a $370 million fund administered by the Department of Defense (DoD) known as the “Peer Reviewed Medical Research Program (PRMRP).” This important breakthrough was a direct result of the nationwide advocacy of the peripheral neuropathy community. This accomplishment has allowed our research community to apply for funding from a federal program to which they previously did not have access. The PRMRP is specifically focused on high-risk, high-reward research that will lead to new, tangible outcomes such as new therapeutics and treatments. Every year, Congress determines the conditions that are eligible for study through the PRMRP by listing them in the Senate version of the annual Defense Appropriations Act. Below are the peripheral neuropathy-related projects that will receive funding as part of the 2021 bill.

2021 PRMRP Awarded Projects:

Simultaneous Voltage and Calcium Imaging from Primary Sensory Neurons in Live Mice:

Principal Investigator: ZHANG, YAN
Institution Receiving Award: TEXAS, UNIVERSITY OF, HEALTH SCIENCE CENTER AT SAN ANTONIO
Program: PRMRP
Proposal Number: PR210388
Award Number: W81XWH-22-1-0076
Funding Mechanism: Discovery Award
Award Amount: $310,000.00

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Discovery of Neuroprotective Small Molecules Against Chemotherapy-Induced Peripheral Neuropathy:

Principal Investigator: PRZEDBORSKI, SERGE
Institution Receiving Award: COLUMBIA UNIVERSITY MEDICAL CENTER
Program: PRMRP
Proposal Number: PR210956
Award Number: W81XWH-22-1-0127
Funding Mechanism: Discovery Award
Award Amount: $322,958.00

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MRI Biomarkers of Traumatic Peripheral Nerve Injury and Repair: Validation and Multisite Application:

Principal Investigator: DORTCH, RICHARD
Institution Receiving Award: ST. JOSEPH’S HOSPITAL AND MEDICAL CENTER
Program: PRMRP
Proposal Number: PR211292
Award Number: W81XWH-22-1-0483
Funding Mechanism: Investigator-Initiated Research Award – Partnering PI Option
Partnering Awards: PR211292P1
Award Amount: $1,628,512.00

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MRI Biomarkers of Traumatic Peripheral Nerve Injury and Repair: Validation and Multisite Application:

Principal Investigator: THAYER, WESLEY P
Institution Receiving Award: VANDERBILT UNIVERSITY MEDICAL CENTER
Program: PRMRP
Proposal Number: PR211292P1
Award Number: W81XWH-22-1-0484
Funding Mechanism: Investigator-Initiated Research Award – Partnering PI Option
Partnering Awards: PR211292
Award Amount: $1,730,000.00

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Nonviral Gene and Reprogramming-Based Cell Therapies for Peripheral Nerve Injury:

Principal Investigator: GALLEGO-PEREZ, DANIEL
Institution Receiving Award: OHIO STATE UNIVERSITY, THE
Program: PRMRP
Proposal Number: PR211321
Award Number: W81XWH-22-1-0392
Funding Mechanism: Investigator-Initiated Research Award – Partnering PI Option
Award Amount: $2,359,841.00

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Nonviral Gene and Reprogramming-Based Cell Therapies for Peripheral Nerve Injury:​

Principal Investigator: ARNOLD, WILLIAM
Institution Receiving Award: OHIO STATE UNIVERSITY, THE
Program: PRMRP
Proposal Number: PR211321P1
Award Number: W81XWH-22-1-0393
Funding Mechanism: Investigator-Initiated Research Award – Partnering PI Option
Award Amount: $790,159.00

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Specialized Lipogenic Macrophages in Diabetic Peripheral Neuropathy:

Principal Investigator: SALISBURY, ELIZABETH
Institution Receiving Award: TEXAS MEDICAL BRANCH, UNIVERSITY OF, GALVESTON
Program: PRMRP
Proposal Number: PR211377
Award Number: W81XWH-22-1-0004
Funding Mechanism: Discovery Award
Award Amount: $316,000.00

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A New Humanized Mouse Model for the Study of Peripheral Neuropathies:

Principal Investigator: ELBAZ-EILON, BENAYAHU
Institution Receiving Award: NORTHWESTERN UNIVERSITY, CHICAGO, ILLINOIS
Program: PRMRP
Proposal Number: PR212048
Award Number: W81XWH-22-1-0386
Funding Mechanism: Discovery Award
Award Amount: $291,332.00

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Tesamorelin Therapy to Enhance Axonal Regeneration, Minimize Muscle Atrophy, and Improve Functional Outcomes Following Peripheral Nerve Injury and Repair:

Principal Investigator: TUFFAHA, SAMI
Institution Receiving Award: JOHNS HOPKINS UNIVERSITY
Program: PRMRP
Proposal Number: PR212195
Award Number: W81XWH-22-1-0257
Funding Mechanism: Clinical Trial Award – with Planning Phase
Award Amount: $362,700.00

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Multiplexed In Vivo Epigenome Engineering for Therapeutic Targeting of Chronic Pain:

Principal Investigator: MALI, PRASHANT
Institution Receiving Award: CALIFORNIA, UNIVERSITY OF, SAN DIEGO
Program: PRMRP
Proposal Number: PR210085
Award Number: W81XWH-22-1-0401
Funding Mechanism: Investigator-Initiated Research Award
Award Amount: $2,528,000.00

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