PN summer web series kicks off in July! Learn more

Kidney Failure


Chronic kidney or renal failure (uremia) occurs when the kidneys gradually fail to function properly. When the kidneys are impaired, fluids and waste products accumulate in the body. This accumulation is toxic for nerves, and in some cases, may cause peripheral neuropathy.

Many conditions can cause kidney failure; the most common are diabetes and high blood pressure.

Since many organs and systems within the body are affected by kidney failure and fluid retention, kidney failure causes a general state of ill health. Also, many complications may occur, including uremic neuropathy—a type of peripheral neuropathy that progresses slowly and may afflict 50% to 100% of people with chronic kidney disease.

Uremic Neuropathy Symptoms

(Not all symptoms and signs may be present.)

Symptoms of uremic neuropathy include:

  • Pain, numbness, and tingling in the feet and legs
  • Feeling of “pins and needles”
  • Paradoxical heat sensation
  • Restless leg syndrome
  • Imbalance
  • Cramps, muscle twitches, or increased pain sensation in the feet and legs
  • Muscle weakness or reduced sensation may occur

Tests for Uremic Neuropathy

(Not all evaluation and tests may be necessary.)

Uremic Neuropathy Treatment

(Not all treatments and therapies may be indicated.)

For relief of uremic neuropathy:

  • Dialysis
  • Kidney transplant
  • Take safety measures to compensate for loss of sensation

A Story of Hope:
Joe and Dana Bacon

Joe and Dana Bacon’s story is a story of hope. They personify all that is good in this world: love, strength, determination. They make you BELIEVE anything is possible. 

The Foundation for Peripheral Neuropathy spoke to Joe and Dana about their life, their inspirations, Dana’s battle with and acceptance of small fiber neuropathy, and Joe’s upcoming Race for a Cure at the Baltimore Marathon.