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Chemo-Induced Peripheral Neuropathy

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Chemotherapy-Induced Peripheral Neuropathy Common, but Underdiagnosed

Chemo-Induced Peripheral Neuropathy, News, Research / By

Dr. Noah Kolb, MD of the University of Utah (a consortium partner of the Foundation’s for Peripheral Neuropathy Research Registry) presented results at the recent American Neurological Association 2015 Annual Meeting that indicated that as many as 50% of patients undergoing chemotherapy for cancer experience chemotherapy-induced peripheral neuropathy, but most cases go undiagnosed and are …

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Nerve Pain Therapy: Botox May Treat Peripheral Neuropathy in Cancer Patients

Chemo-Induced Peripheral Neuropathy, News, PN treatments, Research / By

Neuropathy is a common side effect of certain medications, especially those used in chemotherapy to fight cancer like cisplatin, carboplatin, and oxaliplatin. While symptoms might disappear over time, for some the shooting pain or a loss of feeling in the hands and feet may become chronic. A recent study investigated the effects of Botox B, …

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Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

Chemo-Induced Peripheral Neuropathy, News, Research / By

Chemotherapy-induced peripheral neuropathy (CIPN) is a common treatment-related adverse effect and affects long-term quality of life.1 It has the potential to result in chemotherapy dose reductions and/or early discontinuation.The purpose of this study is to provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult …

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline Read More »

Rodent Models of Chemotherapy-Induced Peripheral Neuropathy

Chemo-Induced Peripheral Neuropathy, News, Research / By

A common complication of chemotherapy is neurotoxicity that often manifests itself as peripheral neuropathy. Many cancer drugs can cause chemotherapy-induced peripheral neuropathy (CIPN), and the incidence can be up to 90%. A significant percentage of patients improve once the offending drug is stopped, but as much as 50% of the affected individuals are left with …

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Ethoxyquin Prevents Chemotherapy-Induced Neurotoxicity via Hsp90 Modulation

Chemo-Induced Peripheral Neuropathy, News, Research / By

A team of researchers has just published their results of a study to determine if there was a way to prevent peripheral neuropathy from pacitaxel, a chemo-therapy drug used to treat solid tumors. Their research may offer a new opportunity for the development of drugs to prevent paclitaxel-induced PN without blocking paclitaxel’s ability to kill …

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Nutraceuticals and Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Systematic Review

Chemo-Induced Peripheral Neuropathy, News, Nutrition, Research / By

A team of researchers at Queensland, School of Medicine, reviewed 24 studies to determine if nutraceuticals (i.e., vitamin E, acetyl-L-carnitine, glutamine, glutathione, alpha lipoic acid, magnesium, and others) are effective in reducing the peripheral neuropathy side effect in patients who have received chemotherapy treatments. The studies were mixed and currently no agent has shown solid …

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Duloxetine May Ease Neuropathy from Chemo

Chemo-Induced Peripheral Neuropathy, News, PN treatments, Research / By

Ellen Lavoie Smith, PhD, University of Michigan School of Nursing, and her team have published results of a phase 3 study showing that patients receiving duloxetine had a reduction in pain symptoms over a 5 week period. And, more patients initially treated with duloxetine, had even greater incidence of pain reduction.  READ MORE from MedPage Today …

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Mayo Researchers Identify Gene Variations that Predict Chemotherapy Side Effects

Chemo-Induced Peripheral Neuropathy, News, Research / By

Small differences in genetic code from one person to the next could influence who develops side effects to chemotherapy. Andreas Butler, MD, oncologist at Mayo Clinic and senior author of the study, reported that three genes (EPHA5, ARHGEF10, and PRX) were the focus of their study and are the first to mine large swaths of …

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MLN9708 Regimen Effective with Reduced Neuropathy Risk in Multiple Myeloma

Chemo-Induced Peripheral Neuropathy, News, Research / By

At the American Society of Hematology annual meeting, Dr. Shaji Kumar presented the results of a recent Phase I/II study conducted at the Mayo Clinic. Newly diagnosed multiple myeloma patients were given an oral regimen containing an experimental preteasome inhibitor – MLN9708. With promising results, more evaluation is being done on relapsed and newly diagnosed myeloma.  …

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