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Capsaicinoids in the Treatment of Neuropathic Pain: A Review

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Abstract: The treatment of neuropathic pain is difficult. Oral pharmaceuticals have significant side effects, and treatment efficacy tends to be modest. The use of topical analgesics reduces the potential for systemic side effects and allows direct application of medications to the area of pain. The natural spicy substance, capsaicin, has historically been known for its …

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Constructing and Deconstructing the Gate Theory of Pain

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Abstract: The gate theory of pain, published by Ronald Melzack and Patrick Wall in Science in 1965, was formulated to provide a mechanism for coding the nociceptive component of cutaneous sensory input. The theory dealt explicitly with the apparent conflict in the 1960s between the paucity of sensory neurons that responded selectively to intense stimuli …

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Neuropathic Pain: Mechanisms and Their Clinical Implications

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Abstract: Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured neurons and along nociceptive and descending modulatory pathways in the central nervous system. The myriad neurotransmitters and other substances involved in the development and maintenance of neuropathic pain also play a part in other neurobiological disorders. This might partly explain the …

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Peripheral Neuropathy Common in Youth with Type 2 Diabetes

Diabetic Peripheral Neuropathy, News, Research / By

Dr. Eva Feldman, MD, PhD, the Russell N. DeJong Professor of Neurology and director of the A. Alfred Taubman Medical Research Institute at the University of Michigan reports that around a quarter of young people with type 2 diabetes also have diabetic peripheral neuropathy, a new pilot study indicates. The prevalence of diabetic peripheral neuropathy …

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Lyme Disease Under-reported, Incidence Still on the Rise

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Lyme disease, one cause of peripheral neuropathy, continues to be the most commonly reported vector-borne illness in the US. It was the 7th most common nationally notifiable disease in 2012 with many cases that go unreported. Three complementary studies are currently being conducted by the CDC to better quantify how many people are actually diagnoed with …

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Chinese Herbal Medicine Lessened Progression to Type 2 Diabetes

Alternative Medicine, Diabetic Peripheral Neuropathy, News, PN treatments, Research / By

Diabetes is the most common cause of peripheral neuropathy. Researchers at the University of Chicago, found that the use of Chinese herbal medicine for 12 months decreased the onset of type 2 diabetes in patients with impaired glucose tolerance by 32.1% compared with placebo. ‘With diabetes evolving into a serious public health burden worldwide, it …

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Sustained Relief of Neuropathic Pain by AAV-Targeted Expression of CBD3 Peptide in Rat Dorsal Root Ganglion

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Scientists from the University of Wisconsin, Department of Anesthesiology, conclude that AAV-encoded CBD3 delivered to peripheral sensory neurons through DRG injection may be a valuable approach for exploring the role of presynaptic VGCCs and long-term modulation of neurotransmission, and may also be considered for development as a gene therapy strategy to treat chronic neuropathic pain.  …

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Tibial Nerve Decompression Failed to Improve Painful Diabetic Polyneuropathy

Diabetic Peripheral Neuropathy, News, Research / By

It has been hypothesized that the development of diabetic polyneuropathy (DPN) is due to swelling of the nerve, as well as thickening and stiffening of the surrounding ligaments, causing chronic compression of nerves. Researchers examined the effect of surgical decompression of the tibial nerve on the mean cross sectional area (CSA). Results indicated there was …

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ADA's 2014 Standards of Care Emphasizes Individualized Treatment

Diabetic Peripheral Neuropathy, News, Research / By

The ADA’s annually revised Standards of Medical Care in Diabetes was just released with an emphasis on individualized treatment of diabetes. Their position paper indicates that, “It is clear that optimal diabetes management requires an organized, systematic approach and involvement of a coordinated team of devoted healthcare professionals…”. The recommendations encourage clinicians to seek various …

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Is α-Synuclein Rising to the Surface as a Diagnostic Biomarker for Parkinson’s Disease?

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The long held hope that a remedy will be discovered to halt the progress of Parkinson disease (PD) will require the identification of early, accurate, and accessible biomarkers. Editors write that if neuronal pathology leading to PD was shown to involve peripheral nerves and be present in a more safely accessible tissue, the ability to …

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