This goal of this study was to develop cutaneous biomarkers for PD. Twenty patients with distal sensory and autonomic neuropathy underwent examinations, autonomic testing, and skin biopsies to measure α-Synuclein density within the epidermis, and nerve fibers that stimulate the sweat glands (sudomotor) and ‘move the hair’ – gooseflesh (pilomotor). READ MORE Source: Neurology
Developed by the British Pain Society, this article highlights the creation of the Map of Medicine care pathway for the management of neuropathic pain. Focusing on treatment by non-specialists, this pathway is based on new evidence, consensus, and the interests of the service users. READ MORE Source: British Journal of Anaesthesia
For years, Richard Dolan knew what it felt like to live with nerve pain. He spent many years suffering with trigeminal neuralgia, a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. Having had “every treatment known to man,” he decided several years ago to have surgery to …
Most clinically available treatments for neuropathic pain, are borrowed from other therapeutic areas (antidepressants, antiepileptics) or involve older therapy (opiods). Patients often receive only partial pain relief. Dr. Miroslav ‘Misha’ Backonja, Department of Neurology, University of Wisconsin, conducted a study to determine if a combination of therapeutic agents is necessary to achieve and maintain satisfactory …
In this review, we bring together three perspectives of placebo research including psychological mechanisms, neurobiological pathways and molecular substrates of placebo analgesia and their contribution to active pain medications. The emphasis is particularly on recent studies illuminating mechanisms underlying individual differences in placebo responsiveness. READ MORE Source: NIH/National Institutes of Health
A study was recently published in the Cochrane Library to reassess the efficacy and safety of opioid agonists for the treatment of neuropathic pain. READ MORE Source: Cochrane Library
The Food and Drug Administration is requiring a stronger warning about the potential for peripheral neuropathy with fluoroquinolone antibiotics that are taken orally or by injection. The warning does not apply to topical formulations, which have not been associated with neuropathy. Drug labels and patient medication guides must be updated, said the agency. READ MORE …
FDA Requires Stronger Peripheral Neuropathy Warning for Quinolones Read More »
A new study suggests that eating more fruit, particularly blueberries, apples and grapes, may reduce the risk of diabetes. The researchers found that for every three weekly servings of blueberries, grapes, and apples, diabetes risk reduced by 26 percent, 12 percent and seven percent, respectively. READ MORE Source:Â Natural Medicines
Research published by Queens University recently indicates that combination therapy remains an important beneficial strategy to treating chronic pain. Though different classes of drugs are being used to treat chronic pain, current medications are limited by incomplete efficacy and dose-limiting side effects. READ MORE Source: The Lancet
A faculty member in the UB medical school has received a $1.2 million federal grant to study the gating mechanism of a temperature-sensitive ion channel protein found abundantly in peripheral nerve endings. The research by Feng Qin, associate professor of physiology and biophysics, on the vanilloid receptor TRPV1 could lead to new drugs that target …
UB Study to Identify Molecular Process Leading to Peripheral Pain Read More »
