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Neuromodulatory Treatments for Chronic Pain: Efficacy and Mechanisms

News, PN treatments, Research / By

Chronic pain is common, and the available treatments do not provide adequate relief for most patients. Neuromodulatory interventions that modify brain processes underlying the experience of pain have the potential to provide substantial relief for some of these patients. The purpose of this Review is to summarize the state of knowledge regarding the efficacy and …

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A Skin Cream for Peripheral Neuropathy? Small Molecule May go a Long Way

Diabetic Peripheral Neuropathy, News, PN treatments, Research / By

About half of people with diabetes develop peripheral neuropathy. While there are some treatments to reduce pain, there’s nothing that restores sensation. Gabriel Corfas, PhD, of the F.M. Kirby Neurobiology Center at Boston Children’s Hospital, wondered if replenishing a growth factor called GDNF (short for glial-derived neurotrophic factor) could improve sensory neurons’ health and function. …

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Neuromodulatory Treatments for Chronic Pain

News, PN treatments, Research / By

Chronic pain is common, and the available treatments do not provide adequate relief for most patients. Neuromodulatory interventions that modify brain processes underlying the experience of pain have the potential to provide substantial relief for some of these patients. The purpose of this Review is to summarize the state of knowledge regarding the efficacy and …

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Pain Management and Prescription Drugs

News, PN treatments, Research / By

Pain is a significant public health problem. Chronic pain alone affects approximately 100 million U.S. adults. Pain reduces quality of life and can affect specific population groups disparately. Currently, large numbers of Americans receive inadequate pain prevention, assessment, and treatment, in part because of the financial incentives that work against the provision of the best, …

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Chinese Herbal Medicine Lessened Progression to Type 2 Diabetes

Alternative Medicine, Diabetic Peripheral Neuropathy, News, PN treatments, Research / By

Diabetes is the most common cause of peripheral neuropathy. Researchers at the University of Chicago, found that the use of Chinese herbal medicine for 12 months decreased the onset of type 2 diabetes in patients with impaired glucose tolerance by 32.1% compared with placebo. ‘With diabetes evolving into a serious public health burden worldwide, it …

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Pharmacologic Management of Diabetic Peripheral Neuropathic Pain

Diabetic Peripheral Neuropathy, News, PN treatments, Research / By

A comprehensive and systematic review of published literature for the treatment of diabetic peripheral neuropathy (DPN) from 1965 through 2012 has been completed at the Brody School of Medicine at East Carolina University and the East Carolina Diabetes and Obesity Institute. Their review showed that neuropathic pain is difficult to diagnose and treat and patients rarely experience …

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New and Developing Drugs for the Treatment of Neuropathic Pain in Diabetes

Diabetic Peripheral Neuropathy, News, PN treatments, Research / By

Dr. Roy Freeman, Beth Israel Deaconess Medical Center, received funding from the NIH to pursue the review of specific drugs, newly approved or in development, to treat neuropathic pain in patients with diabetes. With a variety of drugs under review, the research focused on the mechanisms of action, preclinical supporting data, and adverse effects of …

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Comparative Efficacy of Oral Pharmaceuticals for the Treatment of Chronic Peripheral Neuropathic Pain

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The goal of this study was to assess the efficacy of oral medications on chronic peripheral neuropathy since studies typically report of short-duration outcomes and fail to account for medication tolerability. Seventeen studies were compared and results found that pregabalin and duloxetine had the highest beneficial effects for chronic neuropathic pain.  READ MORE Source: Pain Medicine

Duloxetine and Pregabalin: High-dose monotherapy or their combination?

Diabetic Peripheral Neuropathy, News, PN treatments, Research / By

Duloxetine (ie, Cymbalta, and others) and pregabalin (ie, Lyrica) are used in the first line of treatment for diabetic peripheral neuropathy but have been shown to provide any relief in only about 40% of the patients. This study was focused on whether a combination therapy of duloxetine and pregabilin at standard doses may provide better pain …

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