Dr. Aaron Vinik, MD, PhD, Professor of Medicine and Director of Research at Eastern Virginia Medical School, and his team have developed an FDA-approved device which measures sweat glands to detect levels of peripheral neuropathy in patients with diabetes. READ MORE Source: Healio/Endocrine today
Duloxetine (ie, Cymbalta, and others) and pregabalin (ie, Lyrica) are used in the first line of treatment for diabetic peripheral neuropathy but have been shown to provide any relief in only about 40% of the patients. This study was focused on whether a combination therapy of duloxetine and pregabilin at standard doses may provide better pain …
Duloxetine and Pregabalin: High-dose monotherapy or their combination? Read More »
Researchers in Endocrinology at the university of Tor Vergata, Rome, published a review of available literature dealing with the similarities and differences between painful and painless DPN to try and determine if whether they are the same disease. Some people develop an ‘insensate’ variety of DPN while others experience distressing pain. READ MORE Source: Curr Diab Rep
A team of researchers from the Department of Neurology, Northwestern University, reported on Phase 1/2 results of a study to evaluate the safety and preliminary efficacy of intramuscular injections of plasmid DNA (VM202) expressing two isoforms of hepatocyte growth factor (HGF) in patients with painful diabetic peripheral neuropathy (PDPN). Initial results are that VM202 treatment appeared …
Findings from 3 proof-of-concept studies have been published evaluating the efficacy and safety of carisbamate, a novel neurotherapeutic agent, in the treatment of neuropathic pain. Studies were conducted with patients having postherpetic neuralgia or diabetic peripheral neuropathy for up to 15 weeks. Carisbamate, though well tolerated, did not demonstrate efficacy in neuropathic pain; neither did the …
A controlled clinical study from Boston University School of Medicine and the Veterans Administration indicates that cognitive behavioral therapy (CBT) can help relieve chronic pain for people suffering with type II diabetes. Left untreated, elevated glucose levels can develop into nerve damage, causing painful burning and stinging sensations in the hands and feet. DPN patients …
Behavioral Therapy Eases Pain from Diabetic Neuropathy Read More »
Joanne Moser, MSN, CRNO, and a team of researchers have published a report asking for new guidelines for detection of diabetic peripheral neuropathy in children. Of the 151 children in their study, 26% had a positive screening test for DPN. READ MORE Source: NewsMedical
The total cost of diabetes in the US jumped from $174 billion in 2007, to $245 billion in 2012. Costs in 2012 included $176 billion in direct medical costs and $69 billion in indirect costs, which includes absenteeism, reduced productivity, and unemployment caused by disease-related disability. The full report will be published in the April issue of Diabetes Care. …
Pfizer, Inc. supported a study to characterize the burden of illness among adult patients with DPN receiving treatment in the US. They recruited 112 patients during routine visits at general practitioners and specialist sites who completed a one-time questionnaire that included symptom duration, out-of-pocket costs, validated pain measures, and other assessments. The full study and conclusions are …
Only 22-36% of diabetic peripheral neuropathy patients self-report that they wear prescription footwear regularly, especially at home, according to researchers in the Netherlands. According to their study, which monitored at home usage of prescription footwear, people do not wear their prescription shoes at home enough to prevent recurrent ulcers; it has been shown that ulcer …
Poor Footwear Adherence Led to High Risk for Reulceration in Diabetes Read More »
