News

Nutraceuticals and Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Systematic Review

A team of researchers at Queensland, School of Medicine, reviewed 24 studies to determine if nutraceuticals (i.e., vitamin E, acetyl-L-carnitine, glutamine, glutathione, alpha lipoic acid, magnesium, and others) are effective in reducing the peripheral neuropathy side effect in patients who have received chemotherapy treatments. The studies were mixed and currently no agent has shown solid …

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Living with Pain

Reports show that 50 percent of chronic pain patients consider suicide to escape their physical pain. Neurology Now has just published an uplifting article to help people make the choice to ‘choose life.’  READ MORE Source: NeurologyNow

Phase 1/2 Open-label Dose-escalation Study of Plasmid DNA Expressing Two Isoforms of Hepatocyte Growth Factor in Patients with Painful Diabetic Peripheral Neuropathy

A team of researchers from the Department of Neurology, Northwestern University, reported on Phase 1/2 results of a study to evaluate the safety and preliminary efficacy of intramuscular injections of plasmid DNA (VM202) expressing two isoforms of hepatocyte growth factor (HGF) in patients with painful diabetic peripheral neuropathy (PDPN). Initial results are that VM202 treatment appeared …

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Efficacy and Safety of Carisbamate in Patients with Diabetic Peripheral Neuropathy or Postherpetic Neuralgia

Findings from 3 proof-of-concept studies have been published evaluating the efficacy and safety of carisbamate, a novel neurotherapeutic agent, in the treatment of neuropathic pain. Studies were conducted with patients having postherpetic neuralgia or diabetic peripheral neuropathy for up to 15 weeks. Carisbamate, though well tolerated, did not demonstrate efficacy in neuropathic pain; neither did the …

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Duloxetine May Ease Neuropathy from Chemo

Ellen Lavoie Smith, PhD, University of Michigan School of Nursing, and her team have published results of a phase 3 study showing that patients receiving duloxetine had a reduction in pain symptoms over a 5 week period. And, more patients initially treated with duloxetine, had even greater incidence of pain reduction.  READ MORE from MedPage Today …

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Mayo Researchers Identify Gene Variations that Predict Chemotherapy Side Effects

Small differences in genetic code from one person to the next could influence who develops side effects to chemotherapy. Andreas Butler, MD, oncologist at Mayo Clinic and senior author of the study, reported that three genes (EPHA5, ARHGEF10, and PRX) were the focus of their study and are the first to mine large swaths of …

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Behavioral Therapy Eases Pain from Diabetic Neuropathy

A controlled clinical study from Boston University School of Medicine and the Veterans Administration indicates that cognitive behavioral therapy (CBT) can help relieve chronic pain for people suffering with type II diabetes. Left untreated, elevated glucose levels can develop into nerve damage, causing painful burning and stinging sensations in the hands and feet. DPN patients …

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